EVAg

DNA isolated from cultured virus from a monkey pox positive patient. An unit contains 50ul isolated DNA (Ct value in realtime orthopox PCR approximately 25 when using 5 ul ). NOTE: This material is not available for commercial purposes, such as contract research services”

Human monoclonal recombinant IgG1 targeting the S2 domain of SARS-CoV-2 Spike as determined by ELISA.

Human monoclonal recombinant IgG1 targeting the S1 domain of SARS-CoV-2 Spike as determined by ELISA.

Human monoclonal recombinant IgG1 targeting the S1 domain of SARS-CoV-2 Spike domain of the wild type strain, as determined by ELISA.

Human monoclonal recombinant IgG1 targeting the S2 domain of SARS-CoV-2 Spike as determined by ELISA

Human monoclonal recombinant IgG1 targeting the S2 domain of SARS-CoV-2 Spike domain of the wild type strain, as determined by ELISA.

Serum obtained from rabbits challenged with MERS-CoV.

Through direct cloning and expression of the variable heavy chains (VHHs) of HCAbs from the bone marrow of MERS-CoV infected dromedaries, MERS-CoV specific VHHs or nanobodies were produced. VHH-83 binds with exceptionally high affinity to the receptor binding domain of the viral spike protein. In vitro, this VHH efficiently blocks virus entry at picomolar concentrations

Serum obtained from dromedary camels immunized with a MVA vaccine expressing the spike protein and challenged with MERS-CoV.

HCAb-83 is a MERS-CoV specific camel/human chimeric heavy chain only antibody (HCAb) - composed of the camel VHH-83 linked to a human Fc domain lacking the CH1 exon Through direct cloning and expression of the variable heavy chains (VHHs) of HCAbs from the bone marrow of MERS-CoV infected dromedaries, MERS-CoV specific VHHs or nanobodies were produced. VHH-83 binds with exceptionally high affinity to the receptor binding domain of the viral spike protein. In vitro, HCAb-83 efficiently blocks virus entry at picomolar concentrations