full length plasmid clone of proviral HIV-1; construct produces HIV-1 proteins upon transfection into eukaryotic cells but is non-infectious due to a protease-inactivating mutation in the catalytic centre of the protein (D25N); virus is based on NL-BX
Plasmid contains the entire genome of HIV-1 (NL4-3) with the respective specific mutations in the protease gene. These may confer drug resistance to specific HIV protease inhibitors and have been identified in clinical specimens from individuals with therapeutic failure.
Gp41 recombinant, carrying the "MIF" motif, typical for subtype AE, in the fusion domain of the subtype B prototype NL4-3 - for studying the fusion function
