Product Description
Ref-SKU:
006N-01921 Recombinant HIV-1 virus with the indicated mutations in the protease gene. Mutations have been reported from drug resistant viral variants emerging in vivo, e.g. after treatment with the HIV protease inhibitor saquinavir
Product Risk Group:
Information on the related virus
ICTV Taxonomy:
Virus name:
Subspecies:
Strain:
Isolate:
Genotype:
Cloned Product: Yes
Special feature:
Can it be used to produce GMO:
No
Biosafety restrictions:
Plasmid DNA itself is not infectious unless transfected into suitable cells; will produce live HIV-1 after DNA-transfection of human/mammalian cells
Region encompassed in this Product:
entired virus genome
Plasmid:
Plasmid selection:
TAG:
Sequencing:
Fully sequenced
Sequence controlled:
Yes
Mutations:
No mutation compared to the reference sequence
Storage conditions:
TE Buffer -20C
Shipping conditions:
IATA Classification:
Virus host type:
Note:
This plasmid has been generated as a drug-resistant variant of HIV. It carries mutations that mediate resistance to several clinical protease inhibitors for HIV, including saquinavir
Information about the origin of the product
Recombinant product:
This product is a recombinant product
Biological material origin:
Synthetic origin & Natural origin
Natural part identification: NL4-3
Natural part identification:
NL4-3
Genbank reference:
Collection date: BEFORE
Monday, 26 July, 2021
Country of collection:
Synthetic part identification: point mutations at the indicated positions in the protease gene
Synthetic part identification:
point mutations at the indicated positions in the protease gene
Modifications from the reference sequence(s):
The sequence(s) of this synthetic product has been modified from the sequence listing provided as Genbank references
Description of modification(s) made from the reference sequence(s):
48Val and 90 Met in the viral protease