EVAg

UNIBAS - CH

Core Partner, BSL3, EU

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The entity UNIBAS, DBM-Petersplatz consists of 4 competitive Research Groups (Experimental Virology; Molecular Virology; Transplantation Virology; Experimental Rheumatology), covering basic and applied research. In addition UNIBAS established an accredited diagnostic laboratory for PCR, viral testing, and serology with a strong track record in clinically relevant emerging pathogens, disease-related viruses from transplantation context and immune disorders, and on new test development.

Through our expertise in diagnostics, accredited & quality controlled laboratory operations, and pathogen identification & characterization we will actively contribute materials and know-how to the unique consortium of EVAg. in the centre of university institutes and the University Hospital of Basel, the site is within walking distance to all major research entities in one of the hubs of European pathogen research. The newly appointed managing director, Daniel Pinschewer, was recruited from the University of Geneva, where his laboratory, already previously member of EVA, provided over 140 transnational EVA accesses during the years 2009 - 2013.

The UNIBAS-group is internationally recognized for its contributions to fundamental mechanisms of virus – host interactions, pathogenesis, and immunity, as well as for high-end molecular diagnostic capacity and development, notably in the lentivirus and polyomavirus fields. Our work ranges from the first identification of pathogens and the development of primary detection tools for emerging pathogens (e.g. nation-wide for H5N1 or coronaviruses) to the provision of diagnostic tools (primers, probes, cloning activities and reference materials, etc.) in the same context. These tools enabled diagnostic and investigative virologic activities at UNIBAS, which are widely requested and appreciated. The laboratory UNIBAS at the Department of Biomedicine is specialized in viral diagnostics up to biosafety level 3.

As the Swiss W.H.O. National Reference Centre for polio myelitis our expertise on enteroviruses will also contribute to the foreseen work of the consortium regarding work on the various aspects of RNA viruses. Special expertise on these pathogens: arenaviruses, polyomaviruses, lentiviruses, para- and orthomyxoviruses; we develop and study cell models, animal models, viral pathogenesis, genome identification, molecular characterization and cloning, phenotypic profiling (replicative systems), in vitro pharmacology and inhibitor studies, resistance generation and -characterization.