HSV-1 antiviral-resistant corneal isolate#R7

ANTIVIRAL RESISTANT STRAIN


EVAg

Produced by
: ERASMUS-MC
Shipping From
: Rotterdam - NL

Product Description

Ref-SKU:
011V-02855
This isolate belongs to a unique set of HSV-1 isolates cultured from corneal swabs taken from deceased corneas of otherwise healthy immunecompetent patients with a history of recurrent HSV-1 keratitis in The Netherlands. In-vitro susceptibility profile, and thymidine kinase genotype, have been described for acyclovir, ganciclovir and foscarnet.
Product Risk Group: 
Subspecies: 
type 1
Isolate: 
Isolate#R7
Genotype: 
human herpesvirus 1 (HHV1), herpes simplex virus type 1 (HSV-1)
Serotype: 
human herpesvirus 1 (HHV1), herpes simplex virus type 1 (HSV-1)

Storage conditions: 
Viral Storage Medium -80C
Sequencing: 
Partial sequence
Infectivity: 
Infectivity tested
Mycoplasmic content: 
Not tested

Unit definition: 
0.5 mL infectious culture supernatant

Available within 3 months

500,00 €
(Cost per access for Academics)

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Special feature: 
GMO: 
No
Biosafety restrictions: 
BSL2
Previous Name or Taxonomy: 
Infectivity Test: 
: virus stocks generated in Vero cells. Virus production in culture supernatant was tested by HSV-1 specific PCR and HSV-specific immunefluorescence on infected Vero cells.
Production cell line: 
Shipping conditions: 
Passage: 
5-7
IATA Classification: 
Identification technique: 
HSV-1-specific qPCR
Note: 

Isolate #R7 is acyclovir-resistant, but ganciclovir and foscarnet sensitive (see PMID: 19795980)

Information about the collection of the virus

Collection date: 
Monday, 1 January, 2018
Suspected epidemiological origin : 
Isolation technique: 
virus culture in-vitro
Isolation conditions: 
infection of Vero cells with aliquot virus transport medium containing corneal swab.
Clinical information: 
otherwise healthy immunecompetent patient with recurrent HSV-1 keratitis