This recombinant HIV-1 variant contains a common polymorphism, which has been described as increasing viral replication in the presence of fitness-reducing Pr mutations
full length proviral HIV-1 genome with a TAG stop codon inserted after position 8368 in gp41 (NL4-3), truncating the intracellular domain of gp41; (a stop codon at analogous position have been reported in early reports of SIV propagation in vitro.)